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Multidrug resistance (MDR) expression in chronic myelogenous leukemia (CML)
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First, different cell types respond distinctly to smoke, inflammation, and oxidative stress: airway and alveolar epithelial cells are more susceptible to exogenous stimuli, mitochondrial changes in macrophages may primarily reflect metabolic reprogramming and immune dysfunction, while mitochondrial abnormalities in appendicular skeletal muscle more closely resemble long-term energy metabolism disorders (60, 61)
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