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Thymosin beta-4 (often written as Tβ4 or TB4) is a naturally occurring peptide, and TB-500 (or fequesetide) is a synthetic peptide based on a segment of TB4.3 4 While TB4 is made up of 43 amino acids, TB-500 contains only seven.4 5 Sometimes, especially in earlier research, you may see TB-500 referred to by its amino acid sequence, Ac-LKKTETQ.6 Insider Tip: The “Ac-” before amino acid sequences, like those of peptides, means it’s been permanently modified with an added acetyl group — a process called N-terminal acetylation — to protect it from degradation.7 8 This can improve a peptide’s stability,9 bioavailability,10 and other properties.11 Though nearly all synthetic peptides are protected in one way or another during synthesis, this protection is usually reversible