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In summary, these data support a gut-joint axis in RA, which is based on zonulin-mediated impairment of intestinal barrier function and which is drugable by the zonulin antagonist larazotide
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Both DARA and ISA enhanced cADPR-Hydrolase activity, increasing mean ADPR peak areas from the IgG1 control value (12.08 ± 2.00) to comparable levels (16.91 ± 1.60 and 16.30 ± 2.20, respectively) (inset, Figure 3D )
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