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VDR activation in osteoblasts promotes the synthesis of extracellular matrix proteins, such as type I collagen, osteopontin, and osteocalcin, and increases the expression of osteogenic markers including Runx2, Osx, and ALP (142)
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Besides mediating apoptosis of hepatocytes, TNF-α also induces proliferation of surviving hepatocytes as shown in other models of liver injury, which is a crucial step in the recovery from liver injury (37,38)
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