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Christopher McGowan, M.D., a gastroenterologist specializing in obesity medicine and endobariatrics, explains that in addition to its effects on blood glucose and diabetes, GLP-1 also impacts weight via two key mechanisms: It affects the hunger centers in the brain (specifically, in the hypothalamus), reducing hunger, appetite and cravings

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Those which bind to the B12-IF complex, preventing uptake, those which bind to IF itself, preventing the binding with B12, and those which bind to parietal cells, preventing the production of IF to begin with