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Five strategies significantly reduced the odds of CIN and, among these, NAC (evaluated in 27 trials with a total of 5694 patients) was the most effective (odds ratio 0.77, 95% CI 0.65–0.91, p = 0.002)
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It is currently used clinically to treat syndromes of vascular or degenerative origin characterized by cognitive impairment with decreased intellect, and affective, behavioral, and somatic disorders
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