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Long-lasting pain often means that several mechanisms are active at the same time: nerve irritation, medication tolerance, peripheral branch hypersensitivity, previous dental or surgical trauma, viral nerve injury, muscle spasm, or central sensitization

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We wish to thank Uli Steuerwald and Juergen Warwzinek at the MPIbpC crystallization facility for their support, as well as the Max-Planck-Gesellschaft for funding this work