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Polymorphism of MTHFR and Its Relationship with Hyperhomocysteinemia, Oxidative Stress, and Lipoprotein Modification The C677T polymorphism of the MTHFR gene results in a 50–60% reduction in enzyme activity [143]
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The 2024 NICE update was explicit on one point: do not rule out B12 deficiency just because the standard blood count looks normal
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