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Assay of 35 S-labeled guanosine-5′- O -(3-thio)triphosphate ([ 35 S]GTP γ S) binding to tissue sections, a method for estimating receptor–G protein coupling in situ, indicates that chronic heroin treatment produced pronounced reductions in MOR activity in several brain regions with an upregulation in total opioid receptor number (Sim-Selley et al., 2000)
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The mechanism may refer to the formation of lipid pore, similar to the proteinaceous pores observed in necroptosis and pyroptosis [25]
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