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By inhibiting NNMT, 5-Amino-1MQ reduces 1-MNA formation and alleviates the methyl “sink,” increasing SAM availability for other methylation reactions, while freeing nicotinamide for recycling through NAMPT toward NAD⁺
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However, correlation between NNMT expression and obesity does not prove that pharmacologically reducing NNMT activity with a small molecule will cause fat loss in humans
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