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Key findings include: Decondensation of heterochromatin near centromeres in aging lymphocytes Modulation of histone binding, particularly H1/3 and H1/6 linker histones Enhanced accessibility of genetic material for transcriptional processes Upregulation of neurogenic differentiation markers in stem cells Research suggests Epithalon competes with histones at DNA binding sites, potentially increasing transcriptional activity of genes involved in cellular repair and regeneration
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A Mock-treated and a Puromycin (10 g/ml)-treated condition were used to set the maximal and minimal viability values, respectively, to which the experimental values were normalized
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