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GlyNAC, a newer combination, showed good tolerability in a 2022 study of older adults, though it did not significantly improve the main glutathione outcome across the whole study group

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Other mechanisms that regulate the intracellular iron abundance, such as the exportation of iron via various multivesicular bodies and exosomes carrying ferroportin or prominin2-mediated ferritin, can also affect the cellular sensitivity to ferroptosis, as they deplete the cellular iron and accelerate the lipid peroxidation (53) ( Figure 1 )