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Sangle P, Sandhu O, Aftab Z, Anthony AT, Khan S. Vitamin B12 Supplementation: Preventing Onset and Improving Prognosis of Depre**ion. Cureus. 2020;12(10):e11169. Published 2020 Oct 26. doi:10.7759/cureus.11169

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2.4 Gene UL39 The UL39 gene is situated within the Unique Long Region of the HSV-1 genome and plays a critical role in viral replication and in modulating physiological processes within host cells ( ICP6, which is encoded by the UL39 gene and serves as the large subunit of ribonucleotide reductase, is vital for converting ribonucleotides into deoxyribonucleotides necessary for DNA synthesis in viruses ( Another significant function attributed to ICP6 involves its modulation of programmed cell death (PCD) processes in infected cells through its receptor-interacting protein-homotypic interaction motif (RHIM) ( Inactivation of ICP6 through fusion with LacZ results in restricted virus propagation primarily among dividing cells, particularly tumor cells capable of supplying deoxyribonucleotides via endogenous pathways (59)