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47,75,76,77 Recently, we reported that GH promotes radioresistance in cancer cell lines 78 and that pegvisomant suppresses endometrial tumor regrowth following radiotherapy in a xenograft model, which highlights the potential utility of this combinational approach and identifies GHR antagonism as a potential molecularly targeted radiosensitizing strategy
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Investigation of combination therapies, including combinations of these peptides with each other or with other therapeutic modalities, could potentially improve therapeutic efficacy for certain applications
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