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Paradoxical Decreases in Heart Rate at Low Sub-Therapeutic Doses of Atropine (1) a central vagotonic mechanism , whereby low-dose atropine blocks inhibitory M1 muscarinic receptors in the central nervous system or parasympathetic ganglia, disinhibiting vagal outflow and increasing parasympathetic tone to the sinoatrial node (Kotona et al, 1977
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[DOI] [PMC free article] [PubMed] [Google Scholar] [25].Leiser SF, Fletcher M, Begun A, Kaeberlein M (2013)
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