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However, a sustained increase in erythropoietin leads to the generation of erythrocytes with enhanced sensitivity to some triggers of eryptosis [331]

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Large-scale randomised controlled trials, including the STEP 1 trial (Wilding et al., NEJM 2021) for semaglutide 2.4 mg, have demonstrated clinically meaningful and sustained weight loss in adults with obesity or overweight with weight-related comorbidities