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However, our results on Tα1 potentiation of B reg differentiation in MS (Giacomini et al., 2017), together with its well-characterized pleiotropic activity able to shift inflammation toward a more anti-inflammatory milieu depending on the stimuli or pathological conditions (Romani et al., 2012, Giacomini et al., 2015) and its capacity to induce Treg generation and IL-10 production (Romani et al., 2006, Romani et al., 2017), indicate beneficial and advisable functions for a drug to be used in autoimmune diseases

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It binds to R-binder (haptocorrins) and is transferred to the intrinsic factor (IF) in the intestinal lumen by means of a pH dependent process