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The latter can be caused by complete or partial deficiency of the enzyme methyl­malonyl‑CoA mutase, which requires vitamin B12 as a co-factor (5‑deoxy-adenosyl-cobalamin (Ado‑Cbl)) (Figure 22b.7)

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In addition, while BPC 157 increases NO concentration under inflammation, this can initiate neurodegenerative states such as Alzheimer’s or Parkinson’s diseases, in particular via iron accumulation in the brain [151,152,153]