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The biological importance of SECIS integrity is illustrated by SEPN1-related myopathy, in which point mutations in the invariant AUGA motif of the SELENON SECIS abolish SECISBP2 binding and drastically reduce selenoprotein N expression, causing early-onset muscle disease [47, 48]
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The cohort had median age 56 years (IQR 46, 64), 87.4% male, 61.0% white, with baseline BMI 39.1 (IQR 36.8, 42.5), and 51.1% had diabetes
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