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PT-141, also known as bremelanotide, is a synthetic cyclic heptapeptide melanocortin receptor agonist developed at Palatin Technologies in the early 2000s as a structurally optimised analogue of Melanotan-2. By removing the C-terminal lysine amide of MT-2 and retaining the cyclic Asp-Lys lactam bridge, PT-141 was engineered to preferentially activate the central melanocortin-4 receptor (MC4R) while reducing activity at MC1R and the associated melanogenic effects
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