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Besides, factors related to chronic release of SASPs are also known as pro-fibrotic factors ( 4.1.4 Immune system alterations Abnormal activation of the innate immune system in CKD patients leads to increased pro-inflammatory cytokines (Sato and Yanagita, 2019) and senescence of renal tubular cells ( + CD28 − cells (Yoon et al., 2006)
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