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For context, two peptides in active, much larger human trial programs today: Retatrutide , a triple GIP/GLP-1/glucagon receptor agonist, produced a mean weight change of -24.2 percent at the highest dose tested versus -2.1 percent on placebo in a 48-week Phase 2 trial, with 83 percent of that highest-dose group losing at least 15 percent of body weight versus 2 percent on placebo (Jastreboff et al., NEJM 2023, PMID 37366315)