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Activation of adenosine is also involved in pathophysiological conditions such as cancer, inflammation ( AR subtypes exhibit different affinities for the endogenous agonist ( 1 , A 2A, and A 3 display high to moderate affinity (Ki = 100, 310, and 290 nM, respectively) to adenosine whereas A 2B has low affinity (Ki = 15 μM)
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