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Further mechanistic studies showed that NNMTi increases intracellular NAD⁺ levels and activates the SIRT1 pathway by inhibiting NNMT, thereby suppressing the transcription of adipogenic genes and preventing the maturation of preadipocytes.This research provides a new perspective for understanding the molecular mechanism of adipocyte differentiation, confirms the key role of NNMTi in regulating adipogenesis, and lays a foundation for subsequent obesity intervention studies
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10.3389/fnins.2023.1187758 [DOI] [PMC free article] [PubMed] [Google Scholar] Aliev G., Beeraka N
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