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220 Yet, despite the progress made in the development of carbohydrate-based DC-SIGN inhibitors, only multivalent display of the presented compounds demonstrated inhibitory constants sufficient for the successful application as anti-infectives in preclinical models, such as inhibition of trans-infection of ACE2 + cells by SARS-CoV-2 spike protein-expression vesicular stomatitis virus or SARS-CoV-2 isolates
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