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The frozen tissue blocks were sectioned at 10 µm using a cryotome (Leica Biosystems)
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The results showed that the expression of HMG-R, PCSK-9, and its transcriptional activators, SREBP-2 and HNF-1α, was significantly upregulated, while the LDL-R expression was comparatively downregulated in HCHF rats relative to the control rats
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