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Third, the peptide reduces levels of cleaved caspase-3 and PARP
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282 For example, a patient with positive surgical margins and a hypoxic TME (HIF-1α overexpression) would be predicted to have higher recurrence risk, prompting the inclusion of hypoxia-responsive drug release components and oxygen-generating nanoparticles (e.g, MnO 2 , catalase) in the scaffold design
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