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Multiple sclerosis is associated with both depleted Mn in the cerebrospinal fluid[185] and depleted GSH synthase in the white matter lesions.[309] Cerebellar brain samples taken postmortem from 10 individuals with autism demonstrated an anomalous increase in mRNA expression of excitatory amino acid transporter 1 and glutamate receptor AMPA 1, both involved in the glutamate system.[226] Glutamate receptor binding proteins were also abnormally expressed, and AMPA-type glutamate receptor density was low
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