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Am J Physiol , 1978 For the physique-focused user, the implication is concrete: no IGF-1 elevation means no tissue-growth sides (no carpal tunnel, no water retention, no organ growth, no joint pain, no anabolic upside either), and no GHR-mediated insulin antagonism means no insulin-sensitivity hit — which is the specific reason this peptide slots cleanly into stacks that already carry an IGF-1 and insulin load (HGH, slin, orals)
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