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The glia receptor Sxc- also enhances glutamate release by its exchange with cystine, thereby glutamate binds to presynaptic metabotropic receptors (mGluRs), which provides inhibitory feedback for further release ( Clinical data have supported the underlying hypothesis of imbalances in glutamate homeostasis in addictive brains by showing reductions in GLT-1 levels and of the catalytic union of Sxc-

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This is repeated every 3 to 6 months, depending on the physician’s recommendation

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