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For instance, pharmacokinetic vitamin-drug interaction studies have indicated a decreased uptake of the anticancer drug antifolate methotrexate in cancer cells, and the complexation of methotrexate and doxorubicin C into inactive adducts by riboflavin, thereby reducing the efficacy of these drugs 145
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The C‐terminus of the mTORC2‐specific RICTOR component lies adjacent to the FKBP‐12‐rapamycin‐binding domain of mTOR, obstructing it and therefore rendering it ineffective
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