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Researchers speculated that the benefits of thiamine may arise from improvements in energy metabolism in surviving dopaminergic neurons in the substantia nigra

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Carnosine and Histidine—Iron(II) Chelators of Physiological Significance Carnosine and its closely related analogues are found at relatively high levels in skeletal muscle (2–20 mM) and cardiac muscle (2–10 mM), with lower levels found in the brain, liver, and kidney