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In a landmark 12-month randomized controlled trial in healthy older adults (ages 60-81), MK-677 at 25 mg daily increased GH secretion by 97%, raised IGF-1 levels by 55-88% (restoring them to young adult reference ranges), and produced a statistically significant increase in fat-free mass of 1.1 kg versus a 0.5 kg loss in the placebo group (Nass et al., 2008
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Frias, MD , medical director and principal investigator at Velocity Clinical Research in Los Angeles, said during a presentation
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