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Much of what's currently available falls short of this standard — either lacking a proper single-compound comparison arm, or being limited to a small number of animals, which makes it hard to draw confident conclusions about whether combining the two compounds produces a genuinely additive, synergistic, or simply non-interacting effect

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Another study suggested that oxidative stress-induced 4-hydroxy-2-nonenal (HNE) triggers mitochondrial translocation of AIFM2, promoting apoptosis in cardiac tissues of both mice and humans 40