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Thus, copper deficiency in cardiomyocytes significantly reduces the expression of copper chaperones and the enzymatic activity of CCO, leading to a decrease in left ventricular (LV) copper content and impaired LV contractile function in dilated cardiomyopathy (111)
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however, the mRNA expression level of ACSL4 decreased significantly and the mRNA expression level of GPX4 increased significantly in the RGSH group compared with the AKI group (Fig
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