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One major hurdle in drug development is an incomplete understanding of the underlying mechanisms that drive Aβ plaques and tau-containing neurofibrillary tangles (NFTs) in the brain which may begin decades prior to cognitive decline (9-11)
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In biofluid studies, cerebrospinal fluid ferritin predicts AD outcomes and associates with amyloid and tau measures, supporting disrupted iron homeostasis as an independent driver of disease progression (Du et al., 2024)
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