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The same review describes small studies of creams and serums applied to skin: a 12-week facial cream study in 71 women, a 12-week eye-cream study in 41 women that included placebo and vitamin K cream comparators, a 12-week study comparing GHK-Cu, vitamin C and retinoic acid creams on thigh skin, and an 8-week study of a nano-lipid GHK-Cu formulation against a comparator cream
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