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GST isoforms (GSTM1, GSTP1, GSTT1) are expressed in the cytosol, mitochondria, and nucleus across multiple organs, including the liver, kidneys, lungs, brain, and placenta, exhibiting broad substrate specificity against electrophiles (molecules deficient in electron pairs) and ROS (27–33)
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In red blood cells heterozygous carriers have an enzyme activity of about 50% of the normal mean and normal levels of glutathione [1]
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