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There were no statistically significant differences in proportions of the most frequent self-reported comorbidities, such as arterial hypertension or coronary heart disease (Supplementary Data 2, Supplementary Fig

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While the currently approved DMTs are effective in preventing peripheral immune attacks and as a consequence are useful in preventing focal lesion formation and reducing clinical and radiological relapses, they are less successful in modulating smoldering disease activity and preventing PIRA [29,30]