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Notably, outliers detected both at PRE-START and at the time of DARA treatment failure pointed to biologically distinct, potentially genetically driven MM subgroups with divergent therapeutic responses ( Figure 5 ) confirmed consistent detection of ADO and INO but revealed divergent dynamics, highlighting the need for personalized metabolic monitoring

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Contact your GP promptly if you notice: Sudden or rapid hair loss over a short period Hair loss in patches (which may suggest alopecia areata) Scalp redness, scaling, itching, or scarring Hair loss accompanied by fatigue, weight changes, or other systemic symptoms Hair thinning that does not improve after several months of treating a confirmed deficiency Seek urgent assessment if you develop neurological symptoms such as numbness, tingling, difficulty walking, or balance problems alongside hair loss, as these may indicate significant B12 deficiency requiring prompt treatment to prevent irreversible nerve damage