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Patients typically present with nephritic syndrome, characterized by acute renal failure, hypertension, hematuria, and red blood cell casts
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Curcumin has been repeatedly shown in recent mechanistic studies to downregulate NLRP3 activation, induce autophagy, and up-regulate SIRT1 in relevant cell and animal models, linking these pathways to reduced inflammaging ( Animal studies have provided compelling evidence that polyphenols modulate both innate and adaptive immunity
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