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J Gen Physiol 45:777–799 [DOI] [PMC free article] [PubMed] [Google Scholar] Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, et al

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Activation of HIF-1α signaling by PHD2 deletion under normoxia enhanced glutamine uptake and upregulated GLS1 expression leading to enhanced glutaminolysis and increases in cellular GSH levels and in GSH/GSSG, which correlated with upregulation of antioxidant genes ( SOD1 , SOD2 , catalase , GPx1 , and GR ) and reduction in cellular and mitochondrial ROS production, indicatives of reductive stress (96)