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Some mild soreness, swelling, or bruising at the injection site is completely normal for the first few days and can be managed with ice packs and rest
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treated hESCs with Wnt/β-catenin inhibitor IWR-1 together with activin A and noggin, resulting in induction of PFG gene expression (Touboul et al., 2016), although noggin was later found to impede with the promoting effect of IWR-1 on PFG induction
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