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Under normal conditions, p53 is inactivated by Mdm2 (E3 ligases) through protein-protein binding, promoting the ubiquitination and subsequent degradation of p53 [79]
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"Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach"
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