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Furthermore, it exerts potent antifibrotic effects in pulmonary systems via TGF-β1/Smad3 inhibition, collagen I/III suppression, and PPAR-γ-driven adipogenic reprogramming of lung fibroblasts (evidenced by lipid droplet accumulation and FABP4 upregulation) (Kheirollahi et al., 2019)
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However, it was interesting that the gpx3Δ/Δ mutant had a trend towards less ROS accumulation than the gpxΔ/Δ/Δ/Δ strain or the strains carrying only GPX31 , GPX32 , or GPX33
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