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In cells, more extensive depletion of the glutathione pool by diamide, or lowering the GSH/GSSG ratio to less 50:1 in permeabilized cell, eventually induces PTP opening, as evidenced by an irrevocable ΔΨ m depolarization and loss of matrix markers [9]
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The application of Cd induces an increase in plasma-labeled enzyme activity, and although quercetin does not inhibit this process, it weakens the oxidative damage induced by Cd [125,126]
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