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All the above evidences seem to have a clinical relevance: Polonikov, studying four moderate-severe COVID-19 cases, found that while the three patients with normal/high plasma levels of GSH recovered rapidly, the one with low GSH levels, high plasma ROS and ROS/GSH ratio experienced the most severe illness and, at the date of publication, was still sick (Polonikov, 2020)

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In fact, others have also found that targeting antioxidant capacity using different interventions such as methylcobalamin, folinic acid (57) may be more beneficial in a subgroup of children with this condition