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Through the signaling cascades initiated by the activation of these receptors, butyrate enables neutrophils to better attract other neutrophils to remove unwanted substances, potentially pathogenic substances in the colon [37]
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In the hinge-latch hypothesis, the conformation of the Nrf2–Keap1 complex is altered upon oxidative stress, implying that induction of target genes is only facilitated by newly synthesized Nrf2
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