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Acrolein, a toxic metabolite of CP causes inactivation of microsomal enzymes and results in increased generation of ROS that leads eventually to increased the expression of proinflammatory cytokines 58,59 such as TNF-α and IL-8, which promote ovary apoptosis 60
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Sulfated varieties like sodium laurel ether sulfate, which typically create the most 1,4 dioxane by-product, provide the main cleaning power for countless laundry and dish detergents, hard-surface cleaners, shampoos, and toothpastes
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