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Glutathione is a powerful antioxidant often marketed for brighter, more even skin tone and reduction of dark spots from acne or sun damage. While oral glutathione may offer mild skin brightening effects

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Their experience suggested that the patchy hypopigmentation tended to resolve after 30-40 doses due to the evolution of a uniform skin-lightening effect Depletion of natural hepatic stores of glutathione: Hypothetically, long-term supplementation with any external synthetic compound may signal the body to stop its own production resulting in dependence on synthetic supplements.[39] Depletion of liver glutathione levels (the site of glutathione storage) may be devastating to health